Jianguo Gu1
, Min Zhuo2
, Michael Caterina3
, Amy B MacDermott4
, Annika Malmberg5
, Volker Neugebauer6
and Megumu Yoshimura7 
1Department of Oral & Maxillofacial Surgery, McKnight Brain Institute and College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
2Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
3Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
4Department of Physiology and Cellular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
5Elan Pharmaceuticals, 800 Gateway Boulevard, San Francisco, CA 94080, USA
6Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd. RT 1069, Galveston, TX 77555-1069, USA
7Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan