Jianguo Gu1
, Min Zhuo2
, Michael Caterina3
, Amy B MacDermott4
, Annika Malmberg5
, Volker Neugebauer6
and Megumu Yoshimura7 
1
Department of Oral & Maxillofacial Surgery, McKnight Brain Institute and College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
2
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
3
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
4
Department of Physiology and Cellular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
5
Elan Pharmaceuticals, 800 Gateway Boulevard, San Francisco, CA 94080, USA
6
Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd. RT 1069, Galveston, TX 77555-1069, USA
7
Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan