Table 1

Acid dependent effects on the activation rate of capsaicin-activated responses. Increasing the acidity of the external solution during a 1 second pre-pulse resulted in an increase in the activation rate of capsaicin-evoked currents in rat TRPV1 expressing HEK-293 cells. Values are the mean ± SEM of the calculated activation rate (τ) using a single exponential fit.

Condition

τ (ms)

n


Control (pH 7.4)

1176 ± 195

15

pH 6.8

1021 ± 128

15

pH 6.0

632.0 ± 86.5

13

pH 5.0

242.7 ± 49.7

7


Neelands et al. Molecular Pain 2005 1:28   doi:10.1186/1744-8069-1-28

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