Table 3

Comparison of the antagonist effects of A-425619 at TRPV1 responses evoked by different agonist(s). Values are the calculated IC50's and Hill slopes derived from fits of average normalized responses following the concentration-dependent inhibition by the TRPV1 competitive antagonist A-425619.

ACTIVATOR

IC50 (nM)

Hill Slope


1 μM Capsaicin

20.1

-1.1

pH 5.5

25.9

-1.2

30 nM CAP + pH 5.5

23.2

-1.1

100 nM CAP + pH 5.5

63.6

-0.95

1 μM CAP + pH 5.5

704.0

-0.93


Neelands et al. Molecular Pain 2005 1:28   doi:10.1186/1744-8069-1-28

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