Figure 4.

Cold sensitivity following CFA inflammation of the hindpaw. The latency to withdrawal following intraplantar injection of CFA (n = 6 to 12) is significantly lower than naïve controls (n = 6 to 12) at 15°C, 10°C and 5°C. From this we can conclude that CFA induced inflammation of the hindpaw has both cold allodynic and cold hyperalgesic components. Data are mean ± S.E.M.