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Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing

Kiran Kumar Bali1, Michael Hackenberg2, Avigail Lubin3, Rohini Kuner1 and Marshall Devor3*

Author Affiliations

1 Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, Heidelberg 69120, Germany

2 Department of Genetics, Faculty of Sciences, University of Granada, Granada 18071, Spain

3 Department of Cell & Developmental Biology, Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

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Molecular Pain 2014, 10:22  doi:10.1186/1744-8069-10-22

Published: 19 March 2014

Additional files

Additional file 1: Table S1:

Top 50 miRNAs ranked in order of abundance in the L4 and 5 DRGs of sham operated rats. Table S2. miRNAs nominally up- and down-regulated (p<0.05 before correction for multiple testing) after SNL nerve injury in HA (n=23) and LA rats (n=35; ranked by p-value). SNL-reg was calculated from RPM by the subtraction method: (SNL-sham)/(SNL+sham). None showed significant SNL-reg after FDR correction for multiple testing. Table S3. Top miRNAs ranked by nominal (uncorrected) statistical significance of differential regulation between HA and LA DRGs following SNL nerve injury (subtraction method, HA_SNL1 pool excluded). miRNAs with significant diff-reg after FDR correction (Table 1) are set in italics. Table S4. Top miRNAs ranked by magnitude of differential regulation between HA and LA DRGs following SNL nerve injury (subtraction method). Table S5. miRNAs identified in rat DRGs that have not been previous reported in the rat (miRBase-v19). The ones with the prefix rnoH have homologs of the same number in other species (mostly the mouse). One was listed in the rat miRBase-v20. The ones numbered X1, X2 do not have homologs in any other species (sequence noted).

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