Neither the CB1 antagonist AM251 nor the CB2 antagonist AM630 altered paclitaxel-induced mechanical or cold allodynia. a. No changes in body weight, responsiveness to b. mechanical, or c. cold stimulation were observed in paclitaxel-treated animals receiving AM630 (3 mg/kg/day s.c.) or AM251 (3 mg/kg/day s.c.) relative to Taxol-vehicle animals. *P < 0.05, **P < 0.01, ***P <0.001 vs. Cremophor-Vehicle, ^P < 0.05, ^^P < 0.01, ^^^P < 0.001 Taxol-AM630 (3 mg/kg/day s.c.) and Taxol-AM251 (3 mg/kg/day s.c.) vs. Cremophor-Vehicle, #P < 0.05 vs. Taxol-Vehicle, ϕP < 0.05 Taxol-AM630 (3 mg/kg/day s.c.) and Taxol-AM251 (3 mg/kg/day s.c.) vs. Taxol-Vehicle and Cremophor-Vehicle. Doses are in mg/kg/day s.c. (ANOVA; Dunnett and Tukey post-hoc tests). N = 10–18 per group.
Rahn et al. Molecular Pain 2014 10:27 doi:10.1186/1744-8069-10-27