Figure 6.

Protective effects of WIN55,212-2 and AM1710 on paclitaxel-induced mechanical allodynia following drug removal. a. WIN55,212-2 (0.5 mg/kg/day s.c.) suppressed paclitaxel-induced mechanical allodynia 11 days (day 32) following drug removal. b. AM1710 (3.2 and 0.032 mg/kg/day s.c.) suppressed hypersensitivity to mechanical stimulation up to 17 days following drug removal (until day 38). c. AM1710 (3.2 mg/kg/day s.c.) produced a longer duration of protection against paclitaxel-induced mechanical allodynia relative to WIN55,212-2 (0.5 mg/kg/day s.c.). *P < 0.05, **P < 0.01, ***P <0.001 vs. Cremophor-Vehicle, #P < 0.05, ##P <0.01, ###P <0.001 vs. Taxol-Vehicle, P < 0.05, ⟂⟂P < 0.01, ⟂⟂⟂P < 0.001 Taxol-Agonist (both doses) vs. Taxol-Vehicle, ^P < 0.05 vs. all groups, $P < 0.05, $$$P < 0.001 Taxol-Agonist (both doses) vs. Cremophor-Vehicle, αP < 0.05 Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Cremophor-Vehicle, +P < 0.05, ++P < 0.01, Taxol-AM1710 (3.2 mg/kg/day s.c.) and Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Taxol-Vehicle, ϕP < 0.05, ϕϕP <0.01 Taxol-AM1710 (3.2 mg/kg/day s.c.) vs. Taxol-Vehicle, δP < 0.05, δδP < 0.01 Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Taxol-Vehicle, tP < 0.05, ttP < 0.01 Taxol-AM1710 (3.2 mg/kg/day s.c.) and Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Cremophor-Vehicle (ANOVA; Dunnett and Tukey post hoc tests). N = 4–8 per group.

Rahn et al. Molecular Pain 2014 10:27   doi:10.1186/1744-8069-10-27
Download authors' original image