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Cardiovascular functions of AA and its metabolites |
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| AA Metabolite |
Receptor subtypes |
Secondary messenger mechanisms |
Tissue distribution of the receptors |
Cardiovascular functions of AA metabolites |
Ref. |
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| PGD2 |
DP1, DP2 (CRTH2) |
Gs (DP1, 2), Gi, Gq, MAPK (DP2) |
Leptomeninges, Langerhan cells, Goblet and columnar cells in GI tract, Eosinophils for DP1, All tissues for DP2 |
Vasodilation, Vasoconstriction, Platelet deaggregation |
1, 12 |
| PGE2 |
EP1, EP3, EP3, EP4 |
Gs, Gi, Gq |
Kidney, Lung and Stomach for EP1, EP2 expressed in response to LPS and gonadotrophins, EP3 and 4 in all tissues |
Vasodilation, Vasoconstriction, Maintain renal blood flow and GFR, Vascular smooth muscle mitogenesis |
1, 12, 15 |
| PGI2 |
IP |
Gs (predominant), Gi, Gq |
Neurons, (primarily DRGs), Endothelial cells, Vascular smooth muscle cells, Kidney, Thymus, Spleen and Megakaryocytes |
Vasodilation, Inhibit platelet aggregation, Inhibit TXA2-induced vascular proliferation |
1, 12, 21, 58 |
| PGF2α |
FP |
Gq, EGFR |
Corpus luteum, Kidney, Heart, Lung and Stomach |
Vasoconstriction, Mitogenesis in heart, Inflammatory tachycardia, Renal functions |
1, 12 |
| TXA2 |
TP |
Gq, Gs, Gi, Gh, G12 |
Kidney, Heart, Lungs, Platelets and Immune cells |
Platelet aggregation, Vasoconstriction, Inflammatory tachycardia |
1, 12, 58 |
| 20-HETE |
? |
Gq, Tyrosine kinase, Increased conductance of L-type Ca2+ channels, Inhibition of Na+-K+-2Cl cotransporter |
? |
Renal and cerebral artery contraction, Antagonize EDHF mediated vasorelaxation, Myogenic constriction, Regulate renal functions |
1, 54 |
| Leukotrienes (LTB4-E4) |
BLT1, BLT2 (LTB4), CysLT1, CysLT2 (LTC4-D4) |
?Gi/Go (BLT1,2, CysLT1,2), Gα16 (BLT1,2) |
Leukocytes, spleen, thymus, bone marrow, lymph nodes, heart, skeletal muscle, brain and liver for BLT1, Most tissues for BLT2, |
Coronary smooth muscle contraction, Transient pulmonary and systemic hypertension |
1, 54 |
| EETs |
? |
Gs, Tyrosine kinases, ERK1/2, p38 MAPK, Activation of Ca2+-activated K+ channels |
? |
Renal and cerebral vasodilation, Renal vasoconstriction, Vascular smooth muscle and endothelial cell proliferation |
1 |
Premkumar and Raisinghani Molecular Pain 2006 2:26 doi:10.1186/1744-8069-2-26 |
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