Effects of NVP followed by ifenprodil on NMDA EPSCs in ACC neurons. A, A single example showing the effect of sequential application of NVP (0.4 μM) and ifenprodil (3 μM) on NMDA EPSCs. The insets show average of 3 EPSCs at the time point (1, 2 and 3) indicated in the graph. B, Pooled data showing NVP largely decreased NMDA EPSCs and ifenprodil abolished the residual EPSCs. C, Bar graphs showing the average percentage (left) and decay time constant (right) of NVP- and ifenprodil-sensitive components after sequential application of NVP and ifenprodil.
Wu et al. Molecular Pain 2007 3:11 doi:10.1186/1744-8069-3-11