Table 1

High-priority candidate polymorphisms that may affect motor control.
Gene*
 Molecule
 SNP
 Location
 AA change
 Ref
 Frequency
Function
 Relation to Motor Control
 Total






%
 No


DRD2/ANKK1
 Ankyrin repeat and kinase domain 1
 C32806T
 3' region/Exon 8
 Glu713 Lys
 [42]
 46
 3
 3
 3
 9
GCH1
 GTP cyclohydrolase 1
 C94A
 Exon 1
 Thr 94 Lys
 [14]
 15
 2
 3
 3
 8
GLRA1
 Glycine receptor 1α
 G1192A
 Exon 6
 Arg271 Glu
 [43]
 12
 2
 3
 3
 8
CACNA1S
 Calcium channel, voltage-dependent, L type, α-1S subunit
 T2403C
 Exon 18
 no
 [44]
 25
 3
 2
 3
 8
GABR1A
 GABA A receptor 1 α
 T156C
 Exon 4
 Lys278 Met
 [45]
 28
 2
 3
 3
 8
RyR1
 Ryanodine receptor 1 gene
 G6178T
 Exon 38
 Gly2060 Val
 [46]
 12
 2
 3
 3
 8
ADRA2C
 Adrenergic receptor 2C
 12 NT Ins/Del
 Coding region/3rd intracellular loop
 no
 [47]
 35
 3
 2
 2
 7
5HT2A
 Serotonin 2A receptor
 T102C
 Exon 3
 His 452 Tyr
 [48]
 9
 1
 3
 3
 7
GABBR1
 GABAB receptor gene 1
 G1465A
 Exon 11
 Gly489 Ser
 [49]
 10
 2
 2
 2
 6
ADRA2A
 α2A adrenergic receptor
 C1291G
 Promoter region
 no
 [50]
 26
 2
 2
 2
 6
5HT1A
 Serotonin 1A receptor
 C1019G
 Promoter region
 no
 [51]
 29
 2
 2
 2
 6
CNR1
 Cannabinoid receptor gene 1
 G1359A
 Exon1
 no
 [52]
 31
 3
 0
 2
 5
CHRM1
 Human M1 muscarinic receptor
 C1221T
 Exon 6
 C407
 [53]
 16
 2
 1
 2
 5
Rab3A
 Rat brain associated protein 3A
 C428T
 Exon3
 Val72 Met
 [54]
 26
 2
 1
 2
 5
SCN4a
 Sodium channel receptor gene
 A669G
 Exon 12
 Arg672 Cys
 [55]
 NA
 0
 2
 3
 5

*Genes listed in bold type were genotyped in this study, along with 5 intermediate-priority polymorphisms

Mishra et al. Molecular Pain 2007 3:20   doi:10.1186/1744-8069-3-20