Open Access Research

Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors

Sonia Bhangoo1, Dongjun Ren1, Richard J Miller1, Kenneth J Henry2, Jayana Lineswala2, Chafiq Hamdouchi2, Baolin Li2, Patrick E Monahan3, David M Chan3, Matthew S Ripsch3 and Fletcher A White34*

Author Affiliations

1 Molecular Pharmacology and Structural Biochemistry, Northwestern University, Chicago, IL, USA

2 Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA

3 Cell Biology, Neurobiology & Anatomy, Loyola University – Chicago, Maywood, IL, USA

4 Anesthesiology, Loyola University – Chicago, Maywood, IL, USA

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Molecular Pain 2007, 3:38  doi:10.1186/1744-8069-3-38

Published: 12 December 2007

Additional files

Additional file 1:

The chemical structures and full names of the CCR2 antagonist (CCR2-[R]) and its inactive enantiomer (CCR2-[S]).

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Additional file 2:

Expression of SDF1 mRNA in rat lumbar DRG ipsilateral to focal nerve demyelination. (A) Many cells, both satellite glia and neurons, in the lumbar DRG removed from vehicle-treated rats exhibited SDF1 mRNA transcripts at POD14 (n = 3). (B) SDF1 mRNA expression did not change significantly in the lumbar DRG of LPC-treated rats at POD14 (n = 3). (C) A magnified photomicrograph of the lumbar DRG from a vehicle treated rat. (D) A magnified photomicrograph of the lumbar DRG removed from a LPC-treated rat at POD14.

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