Research
Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors
1 Molecular Pharmacology and Structural Biochemistry, Northwestern University, Chicago, IL, USA
2 Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
3 Cell Biology, Neurobiology & Anatomy, Loyola University – Chicago, Maywood, IL, USA
4 Anesthesiology, Loyola University – Chicago, Maywood, IL, USA
Molecular Pain 2007, 3:38 doi:10.1186/1744-8069-3-38
Published: 12 December 2007Additional files
Additional file 1:
The chemical structures and full names of the CCR2 antagonist (CCR2-[R]) and its inactive enantiomer (CCR2-[S]).
Format: DOC Size: 28KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 2:
Expression of SDF1 mRNA in rat lumbar DRG ipsilateral to focal nerve demyelination. (A) Many cells, both satellite glia and neurons, in the lumbar DRG removed from vehicle-treated rats exhibited SDF1 mRNA transcripts at POD14 (n = 3). (B) SDF1 mRNA expression did not change significantly in the lumbar DRG of LPC-treated rats at POD14 (n = 3). (C) A magnified photomicrograph of the lumbar DRG from a vehicle treated rat. (D) A magnified photomicrograph of the lumbar DRG removed from a LPC-treated rat at POD14.
Format: DOC Size: 586KB Download file
This file can be viewed with: Microsoft Word Viewer
