Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents

doi:10.1186/1744-8069-3-41

Molecular Pain

Volume 3

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Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents

Misaki Matsumoto , Weijiao Xie , Makoto Inoue and Hiroshi Ueda

Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan

author email corresponding author email

Molecular Pain 2007, 3:41doi:10.1186/1744-8069-3-41


Published:	19 December 2007

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Additional file 1:

ChAT-immunoreactivities in the spinal cord and DRG, using a commercially available antibody from a different source (goat anti-ChAT polyclonal antibody, AB144P, Chemicon, CA). (A) ChAT-immunoreactivities in whole spinal cord. (A-1) Representative picture of ChAT-immunohistochemistry in the spinal cord. Many fiber-like structures in the dorsal horn (A-2) and intense ChAT-like signals in the lamina IX region (A-3) were observed. (B) ChAT-immunoreactivities in the DRG. (B-1) Representative pictures of ChAT-immunohistochemistry in the DRG. ChAT signals were found in most cells across the size spectrum (B-2). Scale bar = 50 μm for (A-2, A-3, B-2). (C) Western blot analysis using goat polyclonal antibody indicates one 68-kDa immunoreactive band for ChAT. The 55-kDa immunoreactive band for β-tubulin is also indicated at the bottom. DH: spinal dorsal horn and VH: spinal ventral horn.

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