Figure 3.

Reduction in the nociceptive threshold in various tests following pretreatment with an AS-ODN against ChAT. The threshold represents the weight (paw withdrawal threshold: PWT, in g) required to induce withdrawal behavior in the paw pressure test (A), latency (paw withdrawal latency: PWL, in s) in the thermal paw withdrawal test (B) and minimum intensity (μA) in the EPW test using 5, 250 and 2000 Hz electrical stimuli. Tests of nociception were performed on the 6th day after the start of pretreatments with vehicle (Veh), AS-ODN (AS) or MS-ODN (MS). *p < 0.05 vs. vehicle. Data represent the means ± S.E.M. from experiments using at least 6 mice.