Segmental upregulation of spinal BDNF after hind-paw incision. Representative photomicrographs of BDNF-IR density in the lumbar (L4–L5) (Figure 1A-E) and thoracic segments (T1–T2) (Figure 1F and G) of the spinal cord in the rats after hind-paw incision. In the lumbar segments, the increased BDNF expression in the dorsal horns of the ipsilateral spinal cord was observed at 1 hour (Figure 1A), 6 hours (Figure 1B) and 1 day (Figure 1C) after incision. At 3 days after incision, BDNF expression (Figure 1D) was comparable to the sham-operated control (Figure 1E). No significant difference of BDNF expression in thoracic segments between the control (Figure 1F) and 6 hour after incision (Figure 1G). Bar = 150 μm.
Li et al. Molecular Pain 2008 4:27 doi:10.1186/1744-8069-4-27