Sequestering spinal BDNF attenuates incision-induced allodynia. Effect of anti-BDNF antibody with IT injection (Figure 6A) or IP administration (Figure 6B) on mechanical withdrawal thresholds (g) after hind-paw incision. Single anti-BDNF antibody IT or IP injection or the saline treatment was performed 1 hour before hind-paw incision. Six to eight rats were used in each group. A, IT injection of anti-BDNF antibody dramatically inhibited the allodynia after hind-paw incision (p < 0.01, two-way repeated measure ANOVA). B, Significant difference was present between IP administration of anti-BDNF antibody (10 mg/kg) and saline treatment. *p < 0.05, group with anti-BDNF IP administration vs control by saline injection; **p < 0.01, group with anti-BDNF IT treatment vs the control by saline injection; † p < 0.01, groups after hind-paw incision vs sham-operated control.
Li et al. Molecular Pain 2008 4:27 doi:10.1186/1744-8069-4-27