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Direct activation of Transient Receptor Potential Vanilloid 1(TRPV1) by Diacylglycerol (DAG)

Dong Ho Woo12, Sung Jun Jung4, Mei Hong Zhu3, Chul-Kyu Park3, Yong Ho Kim3, Seog Bae Oh3* and C Justin Lee12*

Author Affiliations

1 Center for Neural Science, Future Fusion Technology Laboratory, Korea Institute of Science and Technology (KIST), Republic of Korea

2 Neuroscience Program, University of Science and Technology (UST), Republic of Korea

3 Department of Physiology and Program in Molecular and Cellular Neuroscience, School of Dentistry, DRI, BK21 Program, Seoul National University, Seoul 110-749, Korea

4 Department of Physiology, College of Medicine, Kangwon National University, Chunchon 200-710, Korea

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Molecular Pain 2008, 4:42  doi:10.1186/1744-8069-4-42

Published: 1 October 2008

Additional files

Additional file 1:

Chelerythrine, a PKC inhibitor, inhibits the tachyphylaxis of capsaicin-induced current. The desensitized current was shown in the subsequent 1 μM capsaicin treatment (left panel) at every 100 s. The inhibition of desensitization was shown in the presence of 1 μM chelerythrine of the internal pipette solution (middle panel). Right panel shows the summary of peak amplitude ratio of second and third divided by the first capsaicin-induced current between in the presence of and in the absence 1 μM chelerythrine.

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