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Open Access Research

Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior

John K Neubert145*, Christopher King1, Wendi Malphurs1, Fong Wong3, James P Weaver1, Alan C Jenkins1, Heather L Rossi14 and Robert M Caudle245

Author Affiliations

1 Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA

2 Department of Oral Surgery, College of Dentistry, University of Florida, Gainesville, FL, USA

3 Department of Prosthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA

4 Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA

5 Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA

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Molecular Pain 2008, 4:43  doi:10.1186/1744-8069-4-43

Published: 1 October 2008

Additional files

Additional file 1:

Movie showing a hairless SKH1-Hrhr mouse testing itself on the operant orofacial device. This movie demonstrates the ease of testing a mouse in an investigator-independent fashion using the operant orofacial device. Note the technician placing the mouse in the testing box at the beginning of the video – this is the last time the technician interacts with the animal during the trial. At ~16 sec, the animal initiates the first successful contact with the thermode and reward bottle. We pan to the computer at ~31 sec to illustrate the online recordings (top trace = reward licking signal; bottom trace = stimulus thermode signal), and at ~43 sec, we demonstrate how the uncompressed, high-speed acquisition signal appears. Please note that each peak on the top trace represents a single lick.

Format: M1V Size: 19.9MB Download file

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