Research
Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior
1 Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA
2 Department of Oral Surgery, College of Dentistry, University of Florida, Gainesville, FL, USA
3 Department of Prosthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA
4 Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA
5 Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA
Molecular Pain 2008, 4:43 doi:10.1186/1744-8069-4-43
Published: 1 October 2008Additional files
Additional file 1:
Movie showing a hairless SKH1-Hrhr mouse testing itself on the operant orofacial device. This movie demonstrates the ease of testing a mouse in an investigator-independent fashion using the operant orofacial device. Note the technician placing the mouse in the testing box at the beginning of the video – this is the last time the technician interacts with the animal during the trial. At ~16 sec, the animal initiates the first successful contact with the thermode and reward bottle. We pan to the computer at ~31 sec to illustrate the online recordings (top trace = reward licking signal; bottom trace = stimulus thermode signal), and at ~43 sec, we demonstrate how the uncompressed, high-speed acquisition signal appears. Please note that each peak on the top trace represents a single lick.
Format: M1V Size: 19.9MB Download file
