Operant reward licking comparison of hairless SKH1-Hrhr versus C57BL/6J wild-type mice. The hairless SKH1-Hrhr mice had significantly greater (+P < 0.05) licking events as compared to the C57BL/6J mice at both neutral (37°C) and hot (47°C) stimulus temperatures (A). When the data was normalized to the neutral temperature (37°C) as a percent baseline for each strain, the differences between the two strains were not significant (N.S.). For both strains, there was a significant decrease (*P < 0.05) in both raw and normalized licking events at 47°C as compared to 37°C, indicating an aversive response elicited by the noxious stimulus temperature.
Neubert et al. Molecular Pain 2008 4:43 doi:10.1186/1744-8069-4-43