Figure 1.

Changes in blood glucose level, body weight and thermal pain sensitivity in mice (Ins-HAD2) injected with STZ. A. After intraperitoneal injection of STZ, within the first week, blood glucose levels significantly increased (filled circles, n = 11, p < 0.001) and remained constant throughout the course of the experiment as compared to control non-diabetic mice (Ins-HAD2) (open circles, n = 6). B. The body weight of diabetic mice remained constant (filled circles, n = 11), but the body weight of control mice increased steadily (open circles, n = 6, p < 0.001) C. PWL of diabetic mice determined every week after injection of STZ show significant changes: exhibited a phase of hyperalgesia (filled circles; n = 33, p < 0.001) between weeks 1 and 4; a phase of hypoalgesia (filled circles; n = 8, p < 0.001) as compared to control non-diabetic mice (open circles, n = 19). Note that the number of mice is decreasing over the course of experiments because unhealthy mice were not tested further on the hot plate. Asterisks (*, **) represent p < 0.05 and p < 0.001, respectively.