Figure 4.

Altered capsaicin-evoked TRPV1-mediated whole cell currents in diabetic mice. Capsaicin (1 μM)-evoked TRPV1-currents were recorded from acutely dissociated DRG neurons from age matched diabetic and non-diabetic mice. A. Representative traces of capsaicin-evoked TRPV1 currents show that the amplitude is larger in hyperalgesic mice and smaller in hypoalgesic mice as compared to responses in control mice. B. Summary graph showing an average fold change in TRPV1-mediated peak currents is significantly larger in hyperalgesic (n = 26 cells, p < 0.05) and smaller in hypoalgesic mice (n = 26 cells, p < 0.05) as compared to age matched control mice (n = 23). Number in the parenthesis represents the number of cells and the asterisks (*) represents p < 0.05.