[3H]RTX binding in DRG neurons and paw skin obtained from STZ-induced diabetic mice. A. Diabetic hyperalgesic and hypoalgesic mice DRG exhibited higher (n = 4 experiments, p < 0.05) and lower (n = 3 experiments, p < 0.05) TRPV1 levels, respectively as compared to control non-diabetic mice. B. Paw tissue obtained from STZ-induced diabetic hyperalgesic and hypoalgesic mice expressed higher (n = 5 experiments, p < 0.05) and lower (n = 5 experiments, p < 0.05) TRPV1 levels, respectively as compared with control non-diabetic mice. Number in the parenthesis represents the number of experiments performed and the asterisk (*) represents p < 0.05.
Pabbidi et al. Molecular Pain 2008 4:9 doi:10.1186/1744-8069-4-9