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Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P

Ewan SJ Smith1, Gregory RC Blass2, Gary R Lewin1 and Thomas J Park2*

1 Dept. of Neuroscience, Max-Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin-Buch, Germany

2 Dept. of Biological Sciences, Univ. of Illinois at Chicago, Chicago, IL, USA

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Molecular Pain 2010, 6:29 doi:10.1186/1744-8069-6-29

Published: 24 May 2010

Additional files

Additional file 1:

Naked mole-rats display low-level spontaneous scratching with the hind paws, similar to mice.

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Additional file 2:

In addition to scratching, naked mole-rats display bouts of vigorous back rubbing against the cage wall after combined intrathecal application of SP and intracutaneous histamine. Presumably the back rubbing is an attempt to scratch its back.

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