Genetic dissociation between mechanical allodynia and dynamic weight bearing (gait) changes following SNI injury in 22 inbred mouse strains. Bars represent mean ± S.E.M. (A) percentage of maximal allodynia and (B) percentage of maximal weight bearing (mean paw print intensity; see Fig. 4B) change, in each strain separately, over 28 days post-operatively, calculated as areas over the time-effect curve using the trapezoidal rule. Robust strain differences (p < 0.001) were obtained for both measures; the individual pattern of strain responses is the subject of a manuscript in preparation. The non-significant correlation between these two measures is shown in graph C; symbols represent individual strains. Note that the trend towards a negative correlation would argue against genetic variability in allodynia and gait changes being produced by similar gene variants.
Mogil et al. Molecular Pain 2010 6:34 doi:10.1186/1744-8069-6-34