Heat-induced CGRP release from isolated rat skin is facilitated by PAR1 activation. A. CGRP release elicited by heat (closed circles, n = 16) was increased approximately two-fold by the rat PAR1-AP SFLLRN-OH (100 μM, open circles, applied during minutes 5 to 20, n = 12,). Points show mean ± SEM; **, p < 0.01 (ANOVA + Scheffé).
Vellani et al. Molecular Pain 2010 6:61 doi:10.1186/1744-8069-6-61