Table 3

Summary of characteristics of DRG neurons from adult and neonatal mice and rats

Adult mouse

Neonatal mouse

Adult rat

Neonatal rat

% of THR-reponsive neurons (Ca imaging)

17.5

15.2

14.5

19.2

% of THR-reponsive neurons (PKCε translocation)

19,4 ± 1,2

17,5 ± 1,5

13,4 ± 2,4

17,8 ± 1,0

% of THR-responsive neurons which are IB4+

0,9 ± 0,1%

1,0 ± 0,5%

0

0

% of THR-responsive neurons responsive to PAR2-AP (Ca imaging)

0

0

0

0

THR sensitizes TRPV1 (Ca imaging)

yes

yes

yes

yes

PAR1-AP and PAR4-AP sensitize TRPV1 (patch clamp)

yes

-

-

yes

Segregation between PAR1 and PAR2 responsiveness (Ca imaging)

yes

yes

yes

yes

Neurons responsive to thrombin from day 1 in vitro

yes

yes

yes

yes

Upregulation by NTN of thrombin-responsiveness (PKCε translocation)

yes

yes

yes

yes

% of neurones responding to PAR2-AP expressing TRPV1 (Ca imaging)

77,8 ± 9,4

91,0 ± 4,9

87,7 ± 6,2

88.6 ± 5.1%

% of neurones responding to PAR2-AP which are IB4+ (Ca imaging)

81.1 ± 8.3

81.8 ± 5,0

-

82.5 ± 6.0%

% of THR-responsive non-neuronal cells in DRG cultures

57,5 ± 5,6%

62,5 ± 9,9%

37,9 ± 7,0%

55,4 ± 3,4%

Vellani et al. Molecular Pain 2010 6:61   doi:10.1186/1744-8069-6-61