Table 1

Four types of temporal neural responses with differential onsets and durations following acupuncture at ST36 (coordinate and t score of peak voxel, P < 0.005, uncorrected; TR = 2s).

Time-varied response

ACUP

Talairach

Transient Response

Hem/BA

x

y

z

t value

Onset TRs

Duration TRs

Middle Cingulate Cortex

R/32

3

19

35

7.62

29

40

Posterior Cingulate Cortex

R/29

6

-46

16

4.58

51

35

Thalamus

VMpo

R

15

-20

7

4.71

31

37

MDvc

R

6

-20

4

11.31

27

48

VPL

L

-15

-17

6

9.31

33

29

Posterior Parietal Cortex

R/7

22

-49

63

5.88

32

36

SI

R/2

65

-22

23

9.03

34

41

Bimodal Response

Perigenual ACC

R/32

3

44

9

5.15

43

216

Amygdala

L

-21

-4

-17

4.30

38

250

Hippocampus

R

27

-15

-12

5.15

54

243

Posterior Insula

L

-56

-34

18

8.90

38

243

Putamen/Claustrum

L

-21

-5

-9

10.45

49

175

Inferior Parietal Cortex

R/40

62

-34

24

12.23

91

239

Cerebellum

L

-12

-80

-21

11.52

63

232

Intermittent Activity

Red Nucleus/SN

L

-6

-18

-2

8.76

47

122

Periaqueductal Gray

R

3

-30

-12

5.83

75

162

RVM

R

6

-26

-38

5.23

77

156

Hypothalamus

R

3

-3

-7

5.36

57

148

SMA

R/6

4

-16

54

4.68

45

131

Sustained Activity

Anterior Insula

R/13

39

20

2

8.50

34

332

SII

L/40

-65

-25

21

8.63

37

241

Prefrontal Cortex

L/47

-36

17

-6

10.01

41

254

Abbreviations: BA-brodmann area; Hem-hemisphere; VMpo-ventromedial posterior nuclear complex; MDvc-ventrocaudal mediodorsal nucleus; VPL-ventroposterior lateral; SI-primary somatosensory cortex; ACC-anterior cingulate cortex; SN-substantia nigra; RVM-rostral ventromedial medulla; SMA-supplementary motor cortex; SII-secondary somatosensory cortex; PFC-prefrontal cortex; L-Left; R-Right.

Bai et al. Molecular Pain 2010 6:73   doi:10.1186/1744-8069-6-73