Increased P-p38 expression in trigeminal ganglia neurons in response to CFA is repressed in rats on a GSE supplemented diet. Sections of the posterolateral portion of the ganglion (V3) were obtained from untreated animals (CON), GSE treated animals (GSE), animals injected with CFA (CFA), or treated with GSE prior to injection of CFA (GSE + CFA). (A) Images of neuron-satellite glial regions stained for P-p38 are shown in the top panels. The bottom panels are the same sections co-stained for P-p38 and DAPI. (B) The average fold change ± SEM of P-p38 staining intensity from control values is reported (n = 3 independent experiments) * P < 0.01 when compared to control levels, while # P < 0.01 when compared to CFA stimulated levels. Magnification bar = 50 μm.
Cady et al. Molecular Pain 2010 6:91 doi:10.1186/1744-8069-6-91