Thalamic mast cell degranulation or density is not changed after carrageenan in neither male nor female rats. There are significant numbers of mast cells in the posterior thalamus which are usually close to blood vessels (examples in A and B). Male and female carrageenan-treated rats do not show differences in percent mast cell degranulation as compared to vehicle, and there are also no significant ipsilateral/contralateral hemisphere differences in percent mast cell degranulation (C, D). Average mast cell number per section is also not significantly different between carrageenan treatments and vehicle in male and female rats, and there are also no significant ipsilateral/contralateral hemisphere differences (E, F).
Xanthos et al. Molecular Pain 2011 7:42 doi:10.1186/1744-8069-7-42