Open Access Highly Accessed Research

DNA methylation of SPARC and chronic low back pain

Maral Tajerian1,2,3†, Sebastian Alvarado4,5†, Magali Millecamps1,2,6, Thomas Dashwood4,5, Kathleen M Anderson7, Lisbet Haglund2,8, Jean Ouellet2,9, Moshe Szyf4,5 and Laura S Stone1,10,2,3,4,6*

1 Alan Edwards Centre for Research on Pain, McGill University, 740 Dr. Penfield Avenue, Montreal, Quebec, H3A 1A4, Canada

2 McGill Scoliosis & Spine Research Group, McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada

3 Department of Neurology and Neurosurgery, McGill University, Faculty of Medicine, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada

4 Department of Pharmacology and Therapeutics, McGill University, Faculty of Medicine, 3655 Promenade Sir William Osler, Montréal, Québec, H3G 1Y6, Canada

5 Sackler Program for Epigenetics & Developmental Psychobiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Québec H3G 1Y6, Canada

6 Faculty of Dentistry, McGill University, 3640 University Street, Montreal, Quebec, H3A 2B2, Canada

7 Department of Physical Medicine & Rehabilitation, University of Minnesota Medical School, 420 Delaware Street S.E., Minneapolis, MN, 55454, USA

8 Orthopaedics Research Laboratory, McGill University Health Centre, 687 Pine Avenue West, Montreal Quebec, H3A 1A1, Canada

9 Division of Orthopaedic Surgery, McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada

10 Department of Anesthesiology, Anesthesia Research Unit, McGill University, Faculty of Medicine, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada

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Molecular Pain 2011, 7:65 doi:10.1186/1744-8069-7-65

Published: 25 August 2011

Additional files

Additional file 1:

Subject information from cadaveric and surgical human IVD samples. Gender, Age and Cause of Death (if applicable) is indicated for all human intervertebral disc samples used in this study.

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Open Data

Additional file 2:

Primer Sequences. Provides the sequences and Tm (°C) for the Bisulfite PCR Primers, Expression Primers, Luciferase Construct Primers and Pyrosequencing Primers used in this study.

Format: PDF Size: 63KB Download file

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Open Data