Generation and characterization of an Advillin-Cre driver mouse line
- Equal contributors
Mouse Biology Unit. European Molecular Biology Laboratory (EMBL), Via Ramarini 32, 00016 Monterotondo (Roma), Italy
Molecular Pain 2011, 7:66 doi:10.1186/1744-8069-7-66Published: 11 September 2011
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.