Figure 1.

Mechanical allodynia and heat hyperalgesia after LNC. EMG activity recorded from the splenius capitis muscle during mechanical (A) or heat (C) stimulation of the tongue. Time-course changes are shown in mean head-withdrawal reflex threshold to mechanical stimulation of the ipsilateral tongue to in LNC- or sham-rats (B) and head-withdrawal reflex threshold to heat stimulation of the ipsilateral tongue to in LNC- or sham-rats (D). Head-withdrawal reflex threshold is indicated by the arrows in A and C. **: p <0.01, ***: p < 0.001 (vs. sham-rats; n = 7 in each group, two-way ANOVA with repeated measures, followed by Bonferroni's multiple-comparison tests).