Paw withdrawal response as a function of Aδ stimulus intensity. Rat hind paws were stimulated at 24 and 48 h following intraplantar drug treatment. After 24 h (A), 2 μg MRS1477 + 30 μg CAP-treated hind paws showed significant analgesia to stimuli at both power settings compared to 30 μg CAP-only and untreated paws (p < 0.0001). After 48 h (B), 2 μg MRS1477 + 30 μg CAP-treated hind paws displayed significant analgesia at all power settings compared to 30 μg CAP-only and untreated controls. Since they were not significantly different from each other, data from the untreated contralateral and 30 μg CAP-only paws were combined in (B). ●2 μg MRS1477 + 30 μg CAP (n = 7). ○1 μg MRS1477 + 30 μg CAP (n = 12). ■30 μg CAP (n = 12). □Contralateral - No Tx (n = 19). ⊠30 μg CAP & Contra (n = 14).
Lebovitz et al. Molecular Pain 2012 8:70 doi:10.1186/1744-8069-8-70