Nav1.7 is upregulated in magnocellular neurosecretory neurons of supraoptic nucleus following salt loading. (A) Magnocellular neurosecretory neurons (MSN) within supraoptic nucleus (SON) of control rats exhibit Nav1.7 immunolabeling. Following salt-loading, MSN display more prominent Nav1.7 immunoreactivity compared to control rats. (B) Quantification of Nav1.7 immunosignal within the SON demonstrates an approximately two-fold increase in Nav1.7 immunofluorescence in SON of salt-loaded rats compared to control rats.
Black et al. Molecular Pain 2013 9:39 doi:10.1186/1744-8069-9-39