Reasearch Awards nomination

Email updates

Keep up to date with the latest news and content from Molecular Pain and BioMed Central.

Open Access Research

Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery

Guangwen Li, Fei Ma, Yanping Gu and Li-Yen Mae Huang*

  • * Corresponding author: Li-Yen M Huang lmhuang@utmb.edu

  • † Equal contributors

Molecular Pain 2013, 9:63  doi:10.1186/1744-8069-9-63

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email info@biomedcentral.com, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

An important reference on the identification of specific PKC phosphorylation site in mu-opioid receptors.

Li-Yen Huang   (2014-01-06 15:43)  University of Texas Medical Branch

Feng et al (2011)* showed that S363 is a major PKC phosphorylation site on mu-opioid receptors (μ-MORs).  The PKC-mediated phosphorylation of the site interrupts receptor-G protein coupling, thus promoting the desensitization of μ-MORs

*Feng B, Li Z Wang JB: Protein kinase C-mediated phosphorylation of the mu-opioid receptor and its effects on receptor signaling.Molecular pharmacology 2011, 79: 768-775.

Competing interests

None declared

top

Post a comment