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Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery

Guangwen Li, Fei Ma, Yanping Gu and Li-Yen Mae Huang*

  • * Corresponding author: Li-Yen M Huang

  • † Equal contributors

Molecular Pain 2013, 9:63  doi:10.1186/1744-8069-9-63

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An important reference on the identification of specific PKC phosphorylation site in mu-opioid receptors.

Li-Yen Huang   (2014-01-06 15:43)  University of Texas Medical Branch

Feng et al (2011)* showed that S363 is a major PKC phosphorylation site on mu-opioid receptors (μ-MORs).  The PKC-mediated phosphorylation of the site interrupts receptor-G protein coupling, thus promoting the desensitization of μ-MORs

*Feng B, Li Z Wang JB: Protein kinase C-mediated phosphorylation of the mu-opioid receptor and its effects on receptor signaling.Molecular pharmacology 2011, 79: 768-775.

Competing interests

None declared


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